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KMID : 1101420190510040468
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Korean Journal of Clinical Laboratory Science
2019 Volume.51 No. 4 p.468 ~ p.474
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Analysis and Usefulness of Microelectrode Recording during Deep Brain Stimulation Surgery in Movement Disorders
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Baek Jae-Seung
Kim Dong-Jun
Kim Dong-Jun
Park Chan-Woo
Lim Sung-Hyuk
Hyun Soon-Chul
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Abstract
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Deep brain stimulation (DBS) is an effective surgical procedure for treating drug refractory movement disorders, and DBS involves delivering high frequency electrical stimulation to deep brain nuclei. Microelectrode recording (MER) is a complementary test that can precisely identify the location of deep brain nuclei, along with MRI correlation, during DBS surgery to improve the surgical outcome and minimize side effects. The purpose of this paper is to analyze the neuro-physiological waveforms and identify the usefulness of MER by analyzing the MER performed during DBS surgery for treating movement disorders. We retrospectively reviewed 28 patients who underwent MER during DBS surgery for movement disorders from January to December 2018. Of the 28 patients, 38 MERs for the subthalamic nucleus (STN), 10 MERs for the globuspallidusinternus (Gpi), and 4 MERs for the ventral intermediate thalamic nucleus (VIM) were performed. In all the cases, the target sites were found and micro-stimulations were used to check for side effects and to readjust the target sites. The clinical symptoms of all 28 patients improved after surgery. In conclusion, MER is a useful test that employs neuro-physiological waveforms to accurately identify the deep brain nuclei, along with MRI correlation, to improve the DBS surgical outcomes for movement disorders and to minimize side effects.
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KEYWORD
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Deep brain stimulation, Intraoperative monitoring, Microelectrode recording, Movement disorders
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